TetrahydrozolineU.S. Brand Names: Eye-Sine™ [OTC]; Geneye�(r) [OTC]; Murine�(r) Tears Plus [OTC]; Optigene�(r) 3 [OTC]; Tyzine�(r); Tyzine�(r) Pediatric; Visine�(r) Advanced Relief [OTC]; Visine�(r) Original [OTC]
Synonyms: Tetrahydrozoline Hydrochloride; Tetryzoline
Generic Available: Yes: Ophthalmic solution
Use: Symptomatic relief of nasal congestion and conjunctival congestion
Pregnancy Risk Factor: C
Adverse Reactions: >10%: Local: Transient stinging Respiratory: Sneezing 1% to 10%: Cardiovascular: Tachycardia, palpitation, hypertension, heart rate Central nervous system: Headache Neuromuscular & skeletal: Tremor Ocular: Blurred vision
Drug Interactions: Increased toxicity: MAO inhibitors can cause an exaggerated adrenergic response if taken concurrently or within 21 days of discontinuing MAO inhibitor; beta-blockers can cause hypertensive episodes and increased risk of intracranial hemorrhage; anesthetics
Stability: Do not use if solution changes color or becomes cloudy
Mechanism of Action: Stimulates alpha-adrenergic receptors in the arterioles of the conjunctiva and the nasal mucosa to produce vasoconstriction
Pharmacodynamics/Kinetics: Onset of action: Decongestant: Intranasal: 4-8 hours Duration: Ophthalmic vasoconstriction: 2-3 hours
Dosage: Nasal congestion: Intranasal: Children 2-6 years: Instill 2-3 drops of 0.05% solution every 4-6 hours as needed, no more frequent than every 3 hours Children >6 years and Adults: Instill 2-4 drops or 3-4 sprays of 0.1% solution every 3-4 hours as needed, no more frequent than every 3 hours Conjunctival congestion: Ophthalmic: Adults: Instill 1-2 drops in each eye 2-4 times/day
Patient Education: Remove contact lenses before using in eye, do not use for more than 72 hours unless directed to do so; consult physician if vision changes or visual acuity occur; do not exceed recommended dosage
Nursing Implications: Monitor blood pressure, heart rate, symptom response
Dental Health: Effects on Dental Treatment: No significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic Precautions: No information available to require special precautions
Mental Health: Effects on Mental Status: None reported
Mental Health: Effects on Psychiatric Treatment: MAO inhibitors can cause an exaggerated adrenergic response if taken concurrently or within 21 days of discontinuing MAO inhibitor; beta-blockers can cause hypertensive episodes and increased risk of intracranial hemorrhage
Dosage Forms: Solution, intranasal, as hydrochloride: Tyzine�(r): 0.1% (15 mL) [spray bottle; contains benzalkonium chloride]; (30 mL) [dropper bottle; contains benzalkonium chloride] Tyzine�(r) Pediatric: 0.05% (15 mL) [spray bottle; contains benzalkonium chloride] Solution, ophthalmic, as hydrochloride: 0.05% (15 mL) Eye-Sine™, Geneye�(r), Optigene�(r) 3: 0.05% (15 mL) [may contain benzalkonium chloride] Murine�(r) Tears Plus: 0.05% (15 mL, 30 mL) [contains benzalkonium chloride] Visine�(r) Advanced Relief: 0.05% (30 mL) [contains benzalkonium chloride and polyethylene glycol] Visine�(r) Original: 0.05% (15 mL, 30 mL) [contains benzalkonium chloride; 15 mL size also available with dropper]
International Brand Names: ABC Spray�(r) (JP); Azoline�(r) (IL); Azulina Llorens�(r) (ES); Bao Ocular Poen�(r) (AR); Berberil N�(r) (DE, LU); Berberil�(r) (PL); Braito�(r) (ID); Burnil�(r) (TR); Caltheon�(r) (DE); Cendo Vision�(r) (ID); Demetil�(r) (IT, RO); Eye-Visol�(r) (TR); Isotic Clearin�(r) (ID); Montevizin�(r) (YU); Murine Plus�(r) (CL); Murine Sore Eyes�(r) (AU); Narbel�(r) (JP); Nasin�(r) (IL); Octilia�(r) (IT, RU, SG); Ocudiafan�(r) (AR); Oftan Starine�(r) (FI); Oftizoline�(r) (CL); Ophtalmin�(r) (DE); Ophta�(r) (TR); Optazine Fresh�(r) (AU); Optizoline�(r) (HK); Rhinopront�(r) (DE, LU); Rhinopront Top�(r) (CH); Starazolin�(r) (PL); Stilla Decongestionante�(r) (IL, IT); Stilla�(r) (IL); Tetrahidrozolina Denver�(r) (AR); Tetrilin�(r) (DE); Typinal�(r) (IL); Tyzine�(r) (BG, CZ, DE, DK, HR, HU, PL, RO, RU, YU); Vasopos�(r) (DE); Vasorinil�(r) (IT); Visine�(r) (AU, BE, BG, CH, CL, EG, FI, HR, HU, ID, IL, IN, IT, MX, PL, PT, RO, RU, SG, SI, TH, TR, YU); Visine Eye Drops�(r) (ZA); Vispring�(r) (ES); Visubril�(r) (AR); Visustrin�(r) (IT); V--Zoline�(r) (IL); Yxin�(r) (DE); Zenkain�(r) (TR)
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