Loratadine and PseudoephedrineU.S. Brand Names: Alavert™ Allergy and Sinus [OTC]; Claritin-D�(r) 12-Hour [OTC]; Claritin-D�(r) 24-Hour [OTC]
Synonyms: Pseudoephedrine and Loratadine
Generic Available: Yes
Canadian Brand Names: Chlor-Tripolon ND�(r); Claritin�(r) Extra; Claritin�(r) Liberator
Use: Temporary relief of symptoms of seasonal allergic rhinitis, other upper respiratory allergies, or the common cold
Pregnancy Risk Factor: B
Pregnancy Implications: See individual agents.
Lactation: Enters breast milk/not recommended
Contraindications: Hypersensitivity to loratadine, pseudoephedrine, or any component of the formulation; use with or within 14 days of MAO inhibitors
Warnings/Precautions: Use with caution in hypertension, diabetes mellitus, ischemic heart disease, increased intraocular pressure, hyperthyroidism, and prostatic hyperplasia. Patients with swallowing difficulties (eg, upper GI narrowing or abnormal esophageal peristalsis) should not use Claritin-D�(r) 24-Hour. Use caution with hepatic or renal impairment; dose adjustment may be required. Safety and efficacy have not been established in children <12 years of age. When used for self medication (OTC use) patients should contact health care provider if fever present or if needed for >7 days.
Adverse Reactions: See individual agents.
Drug Interactions: Loratadine: Substrate (minor) of CYP2D6, 3A4; Inhibits CYP2C19 (moderate), 2D6 (weak) Also see individual agents.
Pharmacodynamics/Kinetics: See individual agents.
Dosage: Children  12 years and Adults: Oral: Claritin-D�(r) 12-Hour: 1 tablet every 12 hours Alavert™ Allergy and Sinus, Claritin-D�(r) 24-Hour: 1 tablet daily Dosage adjustment in renal impairment: Clcr
30 mL/minute: Claritin-D�(r) 12-Hour: 1 tablet daily Claritin-D�(r) 24-Hour: 1 tablet every other day Dosage adjustment in hepatic impairment: Should be avoided
Patient Education: See individual agents. Do not crush, break, or chew tablet. Take with a full glass of water. Breast-feeding precaution: Breast-feeding is not recommended.
Dental Health: Effects on Dental Treatment: Key adverse event(s) related to dental treatment: Pseudoephedrine: Xerostomia (normal salivary flow resumes upon discontinuation).
Dental Health: Vasoconstrictor/Local Anesthetic Precautions: Use with caution since pseudoephedrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response
Mental Health: Effects on Mental Status: Dizziness, drowsiness, nervousness, and insomnia are common; may cause anxiety or depression; may rarely cause hallucinations
Mental Health: Effects on Psychiatric Treatment: Contraindicated with MAO inhibitors
Dosage Forms: Tablet, extended release: Loratadine 10 mg and pseudoephedrine sulfate 240 mg Alavert™ Allergy and Sinus, Claritin-D�(r) 12-hour: Loratadine 5 mg and pseudoephedrine sulfate 120 mg Claritin-D�(r) 24-hour: Loratadine 10 mg and pseudoephedrine sulfate 240 mg
International Brand Names: Chlor-Tripolon ND�(r) (CA); Claritin�(r) Extra (CA); Claritin�(r) Liberator (CA)
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