MedrysoneU.S. Brand Names: HMS Liquifilm�(r)
Generic Available: No
Use: Treatment of allergic conjunctivitis, vernal conjunctivitis, episcleritis, ophthalmic epinephrine sensitivity reaction
Pregnancy Risk Factor: C
Lactation: Excretion in breast milk unknown/use caution
Contraindications: Hypersensitivity to medrysone or any component of the formulation; fungal, viral, or untreated pus-forming bacterial ocular infections; not for use in iritis and uveitis
Warnings/Precautions: Prolonged use has been associated with the development of corneal or scleral perforation and posterior subcapsular cataracts; may mask or enhance the establishment of acute purulent untreated infections of the eye; use caution in patients with glaucoma. Medrysone is a synthetic corticosteroid; structurally related to progesterone; if no improvement after several days of treatment, discontinue medrysone and institute other therapy; duration of therapy: 3-4 days to several weeks dependent on type and severity of disease; taper dose to avoid disease exacerbation. Safety and efficacy have not been established in children <3 years of age.
Adverse Reactions: Frequency not defined: Ocular: Acute anterior uveitis, allergic reactions, blurred vision (mild, temporary), burning, cataracts, conjunctivitis, corneal thinning, corneal ulcers, delayed wound healing, foreign body sensation, glaucoma, IOP increased, keratitis, mydriasis, optic nerve damage, ptosis, secondary ocular infection stinging, visual activity defects
Overdosage/Toxicology: Systemic toxicity is unlikely from the ophthalmic preparation.
Stability: Store at room temperature of 25°C (77°F); protect from freezing
Mechanism of Action: Decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability
Pharmacodynamics/Kinetics: Absorption: Through aqueous humor Metabolism: Hepatic if absorbed Excretion: Urine and feces
Dosage: Children  3 years and Adults: Ophthalmic: Instill 1 drop in conjunctival sac 2-4 times/day up to every 4 hours; may use every 1-2 hours during first 1-2 days
Administration: Ophthalmic: Shake well before using. Do not touch dropper to the eye.
Monitoring Parameters: Intraocular pressure (if duration of therapy is >10 days); periodic examination of lens (with prolonged use)
Patient Education: This medication is only for use in your eyes. Use exactly as directed (see below). May cause sensitivity to light (dark glasses may help); or temporary stinging, burning, or blurred vision. Report pain, swelling, scratchiness, itching, watering, or dryness of eye; drainage, redness, or sign of eye infection; change in vision (eg, double vision, reduced visual field, halo around lights); or worsening of condition or lack of improvement in 3-4 days. Pregnancy/breast-feeding precautions: Inform prescriber if you are pregnant. Consult prescriber if breast-feeding. Wash hands thoroughly before using. Shake well before using. Do not allow applicator tip to touch eye. Gently pull down lower lid and put drop(s) into inner corner of eye. Close eye and roll eyeball in all directions. Do not blink for 30 seconds. Apply gently pressure to inner corner of eye for 30 seconds. Gently wipe away any excess from skin around eye. Do not use any other eye medication for 10-15 minutes.
Anesthesia and Critical Care Concerns/Other Considerations: Medrysone is a synthetic corticosteroid structurally related to progesterone. If no improvement after several days of treatment, discontinue medrysone and institute other therapy. Duration of therapy is 3-4 days to several weeks, dependent on type and severity of disease.
Dental Health: Effects on Dental Treatment: No significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic Precautions: No information available to require special precautions
Mental Health: Effects on Mental Status: None reported
Mental Health: Effects on Psychiatric Treatment: None reported
Dosage Forms: Solution, ophthalmic: 1% (5 mL, 10 mL) [contains benzalkonium chloride]
International Brand Names: HMS Liquifilm�(r) (NL)
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