Mission, Asheville, NC - Cellulose (Oxidized Regenerated). (SEL yoo lose, ...

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Cellulose (Oxidized Regenerated)

Pronunciation:
(SEL yoo lose, OKS i dyzed re JEN er aye ted)

(SEL yoo lose, OKS i dyzed re JEN er aye ted)

U.S. Brand Names: Surgicel�(r); Surgicel�(r) Fibrillar; Surgicel�(r) NuKnit

Synonyms: Absorbable Cotton; Oxidized Regenerated Cellulose

Generic Available: No

Use: Hemostatic; temporary packing for the control of capillary, venous, or small arterial hemorrhage

Use - Dental: To control bleeding created during a dental procedure

Pregnancy Risk Factor: No data reported

Contraindications: Hypersensitivity to any component of the formulation; implantation into bone defects; hemorrhage from large arteries; nonhemorrhagic oozing; use as an adhesion product

Warnings/Precautions: Pain, numbness, or paralysis have been reported if used near a bony or neural space and left inside patient; use minimum amount necessary to achieve hemostasis. Remove as much of agent as possible after hemostasis is achieved. Do not leave in a contaminated or infected space. Always remove completely following hemostasis if applied in proximity to foramina in bone, areas of bony confine, the spinal cord or optic nerve and chasm; product may swell and exert unwanted pressure. The material should not be moistened before insertion since the hemostatic effect is greater when applied dry. The material should not be impregnated with anti-infective agents. Its hemostatic effect is not enhanced by the addition of thrombin.

Adverse Reactions: Frequency not defined.

Central nervous system: Headache

Respiratory: Nasal burning or stinging, sneezing (rhinological procedures)

Miscellaneous: Encapsulation of fluid, foreign body reactions (with or without) infection

Postmarketing and/or case reports: Numbness, pain, paralysis

Drug Interactions: No data reported

Stability: Store at controlled room temperature. Inactivated by autoclaving; do not resterilize. Do not use if package is damaged. Do not reuse after opening.

Mechanism of Action: Cellulose, oxidized regenerated is saturated with blood at the bleeding site and swells into a brownish or black gelatinous mass which aids in the formation of a clot. When used in small amounts, it is absorbed from the sites of implantation with little or no tissue reaction. In addition to providing hemostasis, oxidized regenerated cellulose also has been shown in vitro to have bactericidal properties.

Pharmacodynamics/Kinetics: Absorption: 7-14 days

Dosage: Minimal amounts of the fabric strip are laid on the bleeding site or held firmly against the tissues until hemostasis occurs; remove excess material

Dental Health: Effects on Dental Treatment: No significant effects or complications reported

Dental Health: Vasoconstrictor/Local Anesthetic Precautions: No information available to require special precautions

Dosage Forms:

Fabric, fibrous:

Surgicel�(r) Fibrillar:

1" x 2" (10s)

2" x 4" (10s)

4" x 4" (10s)

Fabric, knitted:

Surgicel�(r) NU-KNIT:

1" x 1" (24s)

1" x 3¹/2" (10s)

3" x 4" (24s)

6" x 9" (10s)

Fabric, sheer weave:

Surgicel�(r):

¹/2" x 2" (24s)

2" x 3" (24s)

2" x 14" (24s)

4" x 8" (24s)

Review Date:
Reviewed By:

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