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American Ginseng

American ginseng

Overview:

Both American and Asian ginsengs belong to the species Panax and are similar in their chemical composition. Siberian ginseng or Eleuthero (Eleutherococcus senticosus ), although part of the same plant family called Araliaceae, is an entirely different plant and does not contain ginsenosides, the active ingredients found in both Asian (Panax ginseng) and American ginseng (Panax quinquefolius ).

There are similarities among American, Asian, and Siberian ginsengs. Each of these three herbs is considered an adaptogen, a substance that strengthens the body, helping it return to normal when it has been subjected to prolonged stress. Therefore, they are considered to be valuable supports for those recovering from illness or surgery, especially the elderly.

The root of American ginseng is light tan and gnarled, sometimes resembles the human body. Panax means all illness, and ginseng has been used across the ages in many different cultures as a "cure-all."

Many studies on ginseng have been performed using Panax ginseng (Asian ginseng). There have been positive reports of using Asian ginseng to treat cancer, heart disease, respiratory problems, fatigue, as well as to boost energy and mental performance and to improve quality of life. However, both American and Asian ginsengs contain ginsenosides, and research does exist on this component. Laboratory studies in animals have reported that American ginseng was effective in boosting the immune system, as an antioxidant, protection against heart attacks and protection against kidney damage caused by methamphetamine use. Research on American ginseng has focused on a number of conditions, some of which are described below.

Attent defecit hyperactivity disorder

An early study suggests that American ginseng, in combination with ginkgo (Ginkgo biloba), may prove to be of value in helping to treat ADHD. More research in this area is needed.

Alzheimer's disease

Individual reports and animal studies indicate that a component of American ginseng and Asian ginseng, the ginsenosides, may slow the progression of Alzheimer's and improve memory and behavior. Studies of large groups of people are needed to best understand this possible use of American ginseng for slowing Alzheimer's or senility.

Cancer

Studies suggests that regular intake of ginseng may reduce one's chances of getting various types of cancer, especially lung, liver, stomach, pancreatic and ovarian. A laboratory study found that American ginseng may also enhance the effects of medications used to treat breast cancer, potentially allowing the doctor to use less chemotherapy.

Diabetes

While both Asian and American ginsengs appear to lower blood sugar (glucose) levels, American ginseng has been the more studied in scientific trials. Several human studies report a blood sugar lowering effect using American ginseng in patients with type 2 diabetes, both on fasting blood sugar and on postprandial (after eating) glucose levels. One study found that people with type 2 diabetes who took American ginseng before or together with a high sugar load experienced less of an increase in blood glucose levels.

Several studies using laboratory animals report positive effects of using American ginseng and ginsenosides for high blood sugar levels. One recent study using mice found that the American ginseng berry was more effective at lowering blood sugar levels than the root.

More research is needed.

Immune system enhancement

American ginseng is believed to enhance the immune system, which could, in theory, help the body fight off infection and disease. In several clinical studies, American ginseng improved the function of cells playing a role in immunity.

Plant Description:

The American ginseng plant has leaves that grow in a circle around a straight stem. Yellowish-green umbrella-shaped flowers grow in the center and produce red berries. Wrinkles around the neck of the root tell how old the plant is. This is important because American ginseng is not ready for use until it has grown for four to six years. American ginseng is very expensive and is now being grown on farms in order to protect the wild American ginseng from over-harvesting.

What's It Made Of?:

American ginseng products are made from ginseng root and the long, thin offshoots called root hairs. The main chemical ingredients of American ginseng are ginsenosides and polysaccharide glycans (quinquefolans A, B, and C). American ginseng seems to be more relaxing than Asian ginseng, which may have stimulating effects.

Available Forms:

American ginseng (dried) is available in water, water-and-alcohol, or alcohol liquid extracts, and in powders, capsules, and tablets. American ginseng is available with other herbs in several combination formulas.

It is important when buying ginseng to read the label carefully and make sure that you are purchasing the type of ginseng that you want. If you are looking for Asian ginseng, make sure you buy Korean, red, or Panax ginseng. If you are looking for American ginseng, buy a Panax quinquifolium. Siberian ginseng or Eleuthero (Eleutherococcus senticosus) and Panax notoginseng may also be found in health food stores or pharmacies.

How to Take It:

Pediatric

This herb is not recommended for use in children unless under the supervision of a qualified health care provider.

Adult

Fresh root: 1 - 2 g, once daily for up to 3 months
Dried root: 1/2 - 2 g, chew and swallow once daily
Tincture (1:5): 1 - 2 teaspoonfuls, 1 - 3 times daily
Fluid extract (1:1): 1/4 - 1/2 teaspoonfuls, 1 - 3 times daily
Standardized extract: 100 - 200 mg, 1 - 3 times daily, standardized to contain 4 - 5% ginsenosides

Precautions:

The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, contain components that can trigger side effects and interact with other herbs, supplements, or medications. For these reasons, herbs should be taken with care, under the supervision of a health care provider qualified in the field of botanical medicine.

Reported side effects of taking ginseng include:

High blood pressure
Insomnia
Restlessness
Anxiety
Euphoria
Diarrhea
Vomiting
Headache
Nosebleed
Breast pain
Vaginal bleeding

To avoid low blood sugar (hypoglycemia), even in people who do not have diabetes, you should take American ginseng with food.

People with hypertension should not take American ginseng products without specific guidance and instruction from a qualified health care provider. At the same time, people with low blood pressure as well as those with an acute illness or diabetes (because of the risk of a sudden drop in blood sugar), should use caution when taking ginseng.

The safety of taking American ginseng during pregnancy is unknown. Therefore, it is not recommended when pregnant or breastfeeding.

American ginseng should be discontinued at least 7 days prior to surgery. American ginseng can lower blood glucose levels and, therefore, create problems for patients fasting prior to surgery. In addition, American ginseng may act as a blood thinner, thereby increasing the risk of bleeding during or after the procedure.

Possible Interactions:

If you are being treated with any of the following medications, you should not use ginseng without first talking to your health care provider:

Anti-Diabetic medications -- American ginseng may lower blood sugar levels. Therefore, this herb may interfere with the effectiveness of blood sugar lowering prescription medications. Talk with your health care provider before using American ginseng if you are taking medicines for diabetes, including insulin and oral hypoglycemic agents.

Blood thinning medications -- Some reports have indicated that ginsenosides may possibly decrease the effectiveness of warfarin, a blood-thinning medication. In addition, ginsenosides may inhibit platelet activity and, therefore, should probably not be used with aspirin either.

Psychiatric medications -- American ginseng may exaggerate the effects of medications used in various psychiatric disorders, so they should not be taken together. There have been reports of a possible interaction between Asian ginseng and the antidepressant medication, phenelzine (which belongs to a class known as monoamine oxidase inhibitors, resulting in symptoms ranging from manic-like episodes to headache and tremulousness

Morphine -- Asian ginseng may block the painkilling effects of morphine.

Supporting Research:

Adams LL, Gatchel RJ. Complementary and alternative medicine: applications and implications for cognitive functioning in elderly populations. Alt Ther. 2000;7(2):52-61.

Ang-Lee MK, Moss J, Yuan C-S. Herbal medicines and perioperative care. JAMA. 2001;286(2):208-216.

Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 1999;58(11):1685-1693.

Briggs CJ, Briggs GL. Herbal products in depression therapy. CPJ/RPC. November 1998;40-44.

Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, Ore: Eclectic Medical; 1998:77.

Carai MAM, Agabio R, Bombardelli E, et al. Potential use of medicinal plants in the treatment of alcoholism. Fitoterapia. 2000;71:S38-S42.

Dey L, Xie JT, Wang A, et al. Anti-hyperglycemic effects of ginseng: comparison between root and berry. Phytomedicine. 2003;10(6-7):600-5.

Duda RB, Zhong Y, Navas V, et al. American ginseng and breast cancer therapeutic agents synergistically inhibit MCF-7 breast cancer cell growth. J Surg Oncol. 1999;72(4):230-239.

Fu Y, Ji LL. Chronic ginseng consumption attenuates age-associated oxidative stress in rats. J Nutr. 2003;133(11):3603-9.

Harkey MR, Henderson GL, Gershwin ME, et al. Variability in commercial ginseng products: an analysis of 25 preparations. Am J Clin Nutr. 2001;73:1101-1106.

Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57(13):1221-1227.

Hsu CC, Ho MC, Lin LC, et al. American ginseng supplementation attenuates creatine kinase level induced by submaximal exercise in human beings. World J Gastroenterol. 2005;11(34):5327-31.

Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs. 2001;61(15):2163-2175.

Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Alt Med Rev. 1999;4(4):249-265.

King ML, Adler SR, Murphy LL. Extraction-dependent effects of American ginseng (Panax quinquefolium) on human breast cancer cell proliferation and estrogen receptor activation. Integr Cancer Ther. 2006;5(3):236-43.

LaValle JB, Krinsky DL, Hawkins EB, et al. Natural Therapeutics Pocket Guide. Hudson, OH:LexiComp; 2000: 442-444.

Lyon MR, Cline JC, Totosy de Zepetnek J, et al. Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study. J Psychiatry Neurosci. 2001;26(3):221-228.

McElhaney JE, Goel V, Toane B, et al. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial. J Altern Complement Med. 2006;12(2):153-7.

Mantle D, Lennard TWJ, Pickering AT. Therapeutic applications of medicinal plants in the treatment of breast cancer: a review of their pharmacology, efficacy and tolerability. Adverse Drug React Toxicol Rev. 2000;19(3):2223-240.

Mantle D, Pickering AT, Perry AK. Medicinal plant extracts for the treatment of dementia: a review of their pharmacology, efficacy, and tolerability. CNS Drugs. 2000;13:201-213.

Miller LG. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158(20):2200-2211.

Murphy LL, Cadena RS, Chavez D, Ferraro JS. Effect of American ginseng (Panax quinquefolium) on male copulatory behavior in the rat. Physiol Behav. 1998;64:445-450.

O'Hara M, Kiefer D, Farrell K, et al. A review of 12 commonly used medicinal herbs. Arch Fam Med. 1998;7(6):523-536.

Ott BR, Owens NJ. Complementary and alternative medicines for Alzheimer's disease. J Geriatr Psychiatry Neurol. 1998;2:163-173.

Predy GN, Goel V, Lovlin R, et al. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ. 2005;173(9):1043-8.

Sui DY, Yu XF, Qu SC, et al. [Protective effect of Panax quinquefolium 20s-proto-panaxdiolsaponins on acute myocardial infarction in dogs]. Zhongguo Zhong Yao Za Zhi. 2001;26(6):416-9.

Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care. 1995;18(10):1373-1375.

Sung J, Han KH, Zo JH, et al. Effects of red ginseng upon vascular endothelial function in patients with essential hypertension. Am J Chin Med. 2000;28(2):205-216.

Takahashi M, Tokuyama S. Pharmacological and physiological effects of ginseng on actions induced by opioids and psychostimulants. Meth Find Exp Clin Pharmacol. 1998;20(1):77-84.

Tode T, Kikuchi Y, Hirata J, et. al. Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int J Gynaecol Obstet. 1999;67:169-174.

Vaes LP, Chyka PA. Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence. Ann Pharmacother. 2000;34(12):1478-1482.

Vladimir V, Sievenpiper JL, Koo VY, et al. American ginseng (Panax quinquifolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med. 2000;160(7):1009-1013.

Vogler BK, Pittler MH, Ernst E. The efficacy of ginseng. A systematic review of randomized clinical trials. Eur J Clin Pharmacol. 1999;55:567-575.

Vuksan V, Sievenpiper JL, Koo VYY, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiaetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med. 2000;160:1009-1013.

Vuksan V, Sievenpiper JL, Xu Z, et al. Konjac-mannan and American ginseng: emerging alternative therapies for type 2 diabetes mellitus. J Am Coll Nutr. 2001;20(5):370S-380S.

Vuksan V, Stavro MP, Sievenpiper JL, et al. Similar postprandial glycemic reactions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care. 2000;23:1221-1226.

Wang M, Guilbert LJ, Li J, et al. A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN-gamma productions in murine spleen cells induced by Con-A. Int Immunopharmacol. 2004;4(2):311-5.

Wargovich MJ. Colon cancer chemoprevention with ginseng and other botanicals. J Korean Med Sci. 2001;16 Suppl:S81-S86.

Wu CF, Liu YL, Song M, et al. Protective effects of pseudoginsenoside-F11 on methamphetamine-induced neurotoxicity in mice. Pharmacol Biochem Behav. 2003;76(1):103-9.

Yeh GY, Eisenberg DM, Kaptchuk TJ, et al. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 2003;26(4):1277-94.

Yuan CS, Wei G, Dey L, et al. Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled Trial. Ann Intern Med 2004;141(1):23-27.

Yun TK, Choi SY. Preventive effect of ginseng intake against various human cancers: A case-control study on 1987 pairs. Cancer Epidemiol Biomarkers Prev. 1995;4:401-408.

Alternative Names: Ginseng - American; Panax quinquefolium

Review Date: 1/25/2007
Reviewed By: Ernest B. Hawkins, MS, BSPharm, RPh, Health Education Resources; and Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.

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